CLUSTAL W (1.83) multiple sequence alignment Z1658_donor -----------------ATGGGTGCGAGAGCGTCARTATTAAGCGGGGGAAAATTAGACT degcon010-degen-30 AGGCTAGAAGGAGAGAGATGGGTGCGAGAGCGTCARTATTAAGCGGGGGAAAATTAGACT HIVGAG1|quiver AGGCTAGAAGGAGAGAGATGGGTGCGAGAGCGTCAGTATTAAGCGGGGGAAAATTAGACT degcon038 AGGCTAGAAGGAGAGAGATGGGTGCGAGAGCGTCAGTATTAAGCGGGGGAAAATTAGACT degcon035 AGGCTAGAAGGAGAGAGATGGGTGCGAGAGCGTCAGTATTAAGCGGGGGAAAATTAGACT Z1658 -----------------ATGGGTGCGAGAGCGTCAGTATTAAGCGGGGGAAAATTAGACT ****************** ************************ Z1658_donor CATGGGAAAAAATTAGGTTAAGGCCAGGGGGAAAGAAACACTATATGATGAAACATYTAG degcon010-degen-30 CATGGGAAAAAATTAGGTTAAGGCCAGGGGGAAAGAAACACTATATGMTGAAACATTTAG HIVGAG1|quiver CATGGGAAAAAATTAGGTTAAGGCCAGGGGGAAAGAAACACTATATGATGAAACATTTAG degcon038 CATGGGAAAAAATTAGGTTAAGGCCAGGGGGAAAGAAACACTATATGATGAAACATTTAG degcon035 CATGGGAAAAAATTAGGTTAAGGCCAGGGGGAAAGAAACACTATATGATGAAACATTTAG Z1658 CATGGGAAAARATTAGGTTAAGGCCAGGGGGAAAGAAACAYTATATGATGAAACATYTAG ********** ***************************** ****** ******** *** Z1658_donor TATGGGCAAGCAGGGAGCTGGRAAGATTTGCACTTAACCCTGGCCTTTTAGARACAYCAG degcon010-degen-30 TATGGGCAAGCAGGGAGCTGGRAAGATTTGCACTTAACCCTGGCCTTTTAGAAACACCAG HIVGAG1|quiver TATGGGCAAGCAGGGAGCTGGGAAGATTTGCACTTAACCCTGGCCTTTTAGAAACACCAG degcon038 TATGGGCAAGCAGGGAGCTGGGAAGATTTGCACTTAACCCTGGCCTTTTAGAAACACCAG degcon035 TATGGGCAAGCAGGGAGCTGGGAAGATTTGCACTTAACCCTGGCCTTTTAGAAACACCAG Z1658 TATGGGCAAGCAGGGAGCTGGRAAGATTTGCACTTAACCCTGGCCTTTTAGAAACAYCAG ********************* ****************************** *** *** Z1658_donor AAGGCTGTAAACAAATAATRMAACAGCTGCAACCAGCTCTTCAGACAGGAACAGAGGAAC degcon010-degen-30 AAGGCTGTAAACAAATAATGAAACAGCTGCAACCAGCTCTTMAGACAGGAACAGAGGAAC HIVGAG1|quiver AAGGCTGTAAACAAATAATGAAACAGCTGCAACCAGCTCTTCAGACAGGAACAGAGGAAC degcon038 AAGGCTGTAAACAAATAATGAAACAGCTGCAACCAGCTCTTCAGACAGGAACAGAGGAAC degcon035 AAGGCTGTAAACAAATAATGAAACAGCTGCAACCAGCTCTTCAGACAGGAACAGAGGAAC Z1658 AAGGCTGTAAACAAATAATRMAACAGCTGCAACCAGCTCTTMAGACAGGAACAGAGGAAC ******************* ******************** ****************** Z1658_donor TTAAATCATTATATAACACAATAGCAACTCTCTATTGTGTACATAAAGGRATAAAGGTAC degcon010-degen-30 TTAAATCATTATATAACACAATAGCAACTCTCTATTGTGTACATARAGGGATAAAGGTAC HIVGAG1|quiver TTAAATCATTATATAACACAATAGCAACTCTCTATTGTGTACATAAAGGGATAAAGGTAC degcon038 TTAAATCATTATATAACACAATAGCAACTCTCTATTGTGTACATAAAGGGATAAAGGTAC degcon035 TTAAATCATTATATAACACAATAGCAACTCTCTATTGTGTACATAAAGGGATAAAGGTAC Z1658 TTARATCATTATATAACACARTAGCAACTCTCTATTGTGTACATARAGGRATAAAGGTAC *** **************** ************************ *** ********** Z1658_donor AAGACACCAAGGAAGCCTTAGACAAGATAGAGGAAGAACAAAACAAAAGCCAGCAARRAA degcon010-degen-30 AAGACACCAAGGAAGCCTTAGACAAGATAGAGGAAGAACAAAACAAAAGCCAGCAARRAA HIVGAG1|quiver AAGACACCAAGGAAGCCTTAGACAAGATAGAGGAAGAACAAAACAAAAGCCAGCAAGGAA degcon038 AAGACACCAAGGAAGCCTTAGACAAGATAGAGGAAGAACAAAACAAAAGCCAGCAAGGAA degcon035 AAGACACCAAGGAAGCCTTAGACAAGATAGAGGAAGAACAAAACAAAAGCCAGCAAGGAA Z1658 AAGACACCAAGGARGCCTTAGACAAGATAGAGGAAGAACAAAACAAAAGCCAGCAARRAA ************* ****************************************** ** Z1658_donor CACAGCAGGCAAAAGCGGCTGACGAAAAGGTCAGTCAAAATTATCCTATAGTGCARAATC degcon010-degen-30 CACAGCAGGCAAAAGCGGCTGACGAAAAGGTCAGTCAAAATTATCCTATAGTGCARAATC HIVGAG1|quiver CACAGCAGGCAAAAGCGGCTGACGAAAAGGTCAGTCAAAATTATCCTATAGTGCAAAATC degcon038 CACAGCAGGCAAAAGCGGCTGACGAAAAGGTCAGTCAAAATTATCCTATAGTGCAAAATC degcon035 CACAGCAGGCAAAAGCGGCTGACGAAAAGGTCAGTCAAAATTATCCTATAGTGCAAAATC Z1658 CACAGCAGGCAAAAGCGGCTGACGAAAAGGTCAGTCAAAATTATCCTATAGTGCARAATC ******************************************************* **** Z1658_donor AMCAAGGACAAATGGTACACCAGGCCATATCACCTAGAACTTTGAATGCATGGGTAAARG degcon010-degen-30 AMCAAGGACAAATGGTACACCAGGCCATATCACCTAGAACTTTGAATGCATGGGTAAARG HIVGAG1|quiver AACAAGGACAAATGGTACACCAGGCCATATCACCTAGAACTTTGAATGCATGGGTAAAAG degcon038 AACAAGGACAAATGGTACACCAGGCCATATCACCTAGAACTTTGAATGCATGGGTAAAAG degcon035 AACAAGGACAAATGGTACACCAGGCCATATCACCTAGAACTTTGAATGCATGGGTAAAAG Z1658 AMCAAGGACAAATGGTACACCAGGCCATATCACCTAGAACTTTGAATGCATGGGTAAAAG * ******************************************************** * Z1658_donor TGATAGAAGAAAAGGCTTTTAGCCCAGAGGTAATACCCATGTTTACAGCATTATCAGAAG degcon010-degen-30 TGATAGAAGAAAAGGCTTTTAGCCCAGAGGTAATACCCATGTTTACAGCATTATCAGAAG HIVGAG1|quiver TGATAGAAGAAAAGGCTTTTAGCCCAGAGGTAATACCCATGTTTACAGCATTATCAGAAG degcon038 TGATAGAAGAAAAGGCTTTTAGCCCAGAGGTAATACCCATGTTTACAGCATTATCAGAAG degcon035 TGATAGAAGAAAAGGCTTTTAGCCCAGAGGTAATACCCATGTTTACAGCATTATCAGAAG Z1658 TRATAGAAGAAAAGGCTTTTAGCCCAGAGGTMATACCCATGTTTACAGCATTATCAGAAG * ***************************** **************************** Z1658_donor GAGCCACCCCTCARGATTTAAACACCATGTTAAATACAGTGGGGGGACATCAAGCAGCCA degcon010-degen-30 GAGCCACCCCTCAAGATTTAAACACCATGTTAAATACAGTGGGGGGACATCAAGCAGCCA HIVGAG1|quiver GAGCCACCCCTCAAGATTTAAACACCATGTTAAATACAGTGGGGGGACATCAAGCAGCCA degcon038 GAGCCACCCCTCAAGATTTAAACACCATGTTAAATACAGTGGGGGGACATCAAGCAGCCA degcon035 GAGCCACCCCTCAAGATTTAAACACCATGTTAAATACAGTGGGGGGACATCAAGCAGCCA Z1658 GAGCCACCCCTCAAGATTTAAACACCATGTTAAATACAGTGGGGGGACATCAAGCAGCCA ************* ********************************************** Z1658_donor TGCAAATGTTAAAAGATACCATYAATGATGAGGCTGCAGAATGGGATAGATTACATCCAG degcon010-degen-30 TGCAAATGTTAAAAGATACCATYAATGATGAGGCTGCAGAATGGGATAGATTACATCCAG HIVGAG1|quiver TGCAAATGTTAAAAGATACCATTAATGATGAGGCTGCAGAATGGGATAGATTACATCCAG degcon038 TGCAAATGTTAAAAGATACCATTAATGATGAGGCTGCAGAATGGGATAGATTACATCCAG degcon035 TGCAAATGTTAAAAGATACCATTAATGATGAGGCTGCAGAATGGGATAGATTACATCCAG Z1658 TGCAAATGTTRAAAGATACCATYAATGATGAGGCTGCAGAATGGGATAGATTACATCCAG ********** *********** ************************************* Z1658_donor TACATGCAGGGCCTATTGCACCAGGCCAAATGAGAGAACCAAGGGGAAGTGACATAGCAG degcon010-degen-30 TACATGCAGGGCCTATTGCACCAGGCCAAATGAGAGAACCAAGGGGAAGTGACATAGCAG HIVGAG1|quiver TACATGCAGGGCCTATTGCACCAGGCCAAATGAGAGAACCAAGGGGAAGTGACATAGCAG degcon038 TACATGCAGGGCCTATTGCACCAGGCCAAATGAGAGAACCAAGGGGAAGTGACATAGCAG degcon035 TACATGCAGGGCCTATTGCACCAGGCCAAATGAGAGAACCAAGGGGAAGTGACATAGCAG Z1658 TACATGCAGGGCCTATTGCACCAGGCCAAATGAGAGAACCAAGGGGAAGTGACATAGCAG ************************************************************ Z1658_donor GAACTACTAGTACCCTTCAGGAACAAATAGCATGGATGACAAATAAYCCACCCATTCCAG degcon010-degen-30 GAACTACTAGTACCCTTCAGGAACAAATAGCATGGATGACAAATAAYCCACCCATTCCAG HIVGAG1|quiver GAACTACTAGTACCCTTCAGGAACAAATAGCATGGATGACAAATAACCCACCCATTCCAG degcon038 GAACTACTAGTACCCTTCAGGAACAAATAGCATGGATGACAAATAACCCACCCATTCCAG degcon035 GAACTACTAGTACCCTTCAGGAACAAATAGCATGGATGACAAATAACCCACCCATTCCAG Z1658 GAACTACTAGTACCCTTCAGGAACAAATAGCATGGATGACAAATAACCCACCCATTCCAG ********************************************** ************* Z1658_donor TGGGAGAAATATATAAAAGATGGATAATTCTGGGATTAAAYAAAATAGTAAGAATGTATA degcon010-degen-30 TGGGAGAAATATATAAAAGATGGATAATTCTGGGATTAAATAAAATAGTAAGAATGTATA HIVGAG1|quiver TGGGAGAAATATATAAAAGATGGATAATTCTGGGATTAAATAAAATAGTAAGAATGTATA degcon038 TGGGAGAAATATATAAAAGATGGATAATTCTGGGATTAAATAAAATAGTAAGAATGTATA degcon035 TGGGAGAAATATATAAAAGATGGATAATTCTGGGATTAAATAAAATAGTAAGAATGTATA Z1658 TGGGAGAAATATATAAAAGATGGATAATTCTRGGATTAAATAAAATAGTAAGAATGTATA ******************************* ******** ******************* Z1658_donor GCCCTGTCAGCATTTTGGACATAAAACARGGGCCAAAGGAACCCTTTAGAGAYTATGTAG degcon010-degen-30 GCCCTGTCAGCATTTTGGACATAAAACARGGGCCAAAGGAACCCTTTAGAGAYTATGTAG HIVGAG1|quiver GCCCTGTCAGCATTTTGGACATAAAACAGGGGCCAAAGGAACCCTTTAGAGATTATGTAG degcon038 GCCCTGTCAGCATTTTGGACATAAAACAGGGGCCAAAGGAACCCTTTAGAGATTATGTAG degcon035 GCCCTGTCAGCATTTTGGACATAAAACAGGGGCCAAAGGAACCCTTTAGAGATTATGTAG Z1658 GCCCTGTCAGCATTTTGGACATAAARCAGGGGCCAAAGGAACCCTTTAGAGACTATGTAG ************************* ** *********************** ******* Z1658_donor AYCGGTTCTTTAAAACTTTAAGAGCTGAACAAGCTACACAAGAAGTAAAARRTTGGATGA degcon010-degen-30 AYCGGTTCTTTAAAACTTTAAGAGCTGAACAAGCTACACAAGAAGTAAAAAATTGGATGA HIVGAG1|quiver ACCGGTTCTTTAAAACTTTAAGAGCTGAACAAGCTACACAAGAAGTAAAAAATTGGATGA degcon038 ACCGGTTCTTTAAAACTTTAAGAGCTGAACAAGCTACACAAGAAGTAAAAAATTGGATGA degcon035 ACCGGTTCTTTAAAACTTTAAGAGCTGAACAAGCTACACAAGAAGTAAAAAATTGGATGA Z1658 AYCGGTTCTTTAAAACTYTAAGAGCTGAACAAGCTACACAAGAAGTAAAAAATTGGATGA * *************** ******************************** ******** Z1658_donor CAGACACMTTGCTGRTCCAAAATGCAAACCCAGATTGTAAGWSCATTTTAAAAGCATTAG degcon010-degen-30 CAGACACMTTGCTGRTCCAAAATGCAAACCCAGATTGTAAGWSCATTTTAAAAGCATTAG HIVGAG1|quiver CAGACACCTTGCTGGTCCAAAATGCAAACCCAGATTGTAAGTCCATTTTAAAAGCATTAG degcon038 CAGACACCTTGCTGGTCCAAAATGCAAACCCAGATTGTAAGTCCATTTTAAAAGCATTAG degcon035 CAGACACMTTGCTGGTCCAAAATGCAAACCCAGATTGTAAGTCCATTTTAAAAGCATTAG Z1658 CAGACACMTTGCTGRTCCAAAATGCAAACCCAGATTGTAAGTCCATTTTAAAAGCATTAG ******* ****** ************************** ***************** Z1658_donor GATCAGGGGCTSCATTAGAAGAAATGATGACAGCATGTCARGGAGTGGGAGGACCTAGCC degcon010-degen-30 GATCAGGGGCTWCATTAGAAGAAATGATGACAGCATGTCARGGAGTGGGAGGACCWAGCC HIVGAG1|quiver GATCAGGGGCTTCATTAGAAGAAATGATGACAGCATGTCAAGGAGTGGGAGGACCTAGCC degcon038 GATCAGGGGCTTCATTAGAAGAAATGATGACAGCATGTCAAGGAGTGGGAGGACCTAGCC degcon035 GATCAGGGGCTTCATTAGAAGAAATGATGACAGCATGTCAAGGAGTGGGAGGACCWAGCC Z1658 GATCAGGGGCTACATTAGAAGAAATGATGACAGCATGTCAAGGAGTGGGAGGACCAAGCC *********** **************************** ************** **** Z1658_donor ACAAAGCAAGAGTRTTGGCTGAGGCAATGAGCCAAGCACACAGTACAAACATACTGATGC degcon010-degen-30 ACAAAGCAAGAGTRTTGGCTGAGGCAATGAGCCAAGCACAAAGTACAAACATACTGATGC HIVGAG1|quiver ACAAAGCAAGAGTATTGGCTGAGGCAATGAGCCAAGCACAAAGTACAAACATACTGATGC degcon038 ACAAAGCAAGAGTATTGGCTGAGGCAATGAGCCAAGCACAAAGTACAAACATACTGATGC degcon035 ACAAAGCAAGAGTATTGGCTGAGGCAATGAGCCAAGCACAAAGTACAAACATACTGATGC Z1658 ACAAAGCAAGAGTRTTGGCTGAGGCAATGAGCCAAGCACAAAGTACAAACATACTGATGC ************* ************************** ******************* Z1658_donor AGAGAAGCAATTTTAAAGGCCCTAAAAGAATWGTTAAATGTTTCAATTGTGGCAARGAAG degcon010-degen-30 AGAGAAGCAATTTTAAAGGCCCTAAAAGAATWGTTAAATGTTTCAATTGTGGCAAAGAAG HIVGAG1|quiver AGAGAAGCAATTTTAAAGGCCCTAAAAGAATAGTTAAATGTTTCAATTGTGGCAAAGAAG degcon038 AGAGAAGCAATTTTAAAGGCCCTAAAAGAATAGTTAAATGTTTCAATTGTGGCAAAGAAG degcon035 AGAGAAGCAATTTTAAAGGCCCTAAAAGAATWGTTAAATGTTTCAATTGTGGCAAAGAAG Z1658 AGAGAAGCAATTTTAAAGGCCCTAAAAGAATAGTTAAATGTTTCAATTGTGGCAAAGAAG ******************************* *********************** **** Z1658_donor GGCACATAGCCAGAAATTGCAGGGCCCCTAGGAAAAAGGGCTGTTGGAARTGTGGAAAGG degcon010-degen-30 GGCACATAGCCAGAAATTGCAGGGCCCCTAGGAAAAAGGGCTGTTGGAARTGTGGAAAGG HIVGAG1|quiver GGCACATAGCCAGAAATTGCAGGGCCCCTAGGAAAAAGGGCTGTTGGAAATGTGGAAAGG degcon038 GGCACATAGCCAGAAATTGCAGGGCCCCTAGGAAAAAGGGCTGTTGGAAATGTGGAAAGG degcon035 GGCACATAGCCAGAAATTGCAGGGCCCCTAGGAAAAAGGGCTGTTGGAAATGTGGAAAGG Z1658 GGCACATAGCCAGAAATTGCAGGGCCCCTAGGAAAAAGGGCTGTTGGAAATGTGGAAAGG ************************************************* ********** Z1658_donor AAGGACACCAAATGAAAGACTGTAAT---GAGAGACAGGCCAATTTTTTAGGGAGAATTT degcon010-degen-30 AAGGACACCAAATGAAAGACTGTAATAATGAGAGACAGGCCAATTTTTTAGGGAGAATTT HIVGAG1|quiver AAGGACACCAAATGAAAGACTGTAATAATGAGAGACAGGCCAATTTTTTAGGGAGAATTT degcon038 AAGGACACCAAATGAAAGACTGTAATAATGAGAGACAGGCCAATTTTTTAGGGAGAATTT degcon035 AAGGACACCAAATGAAAGACTGTAATAATGAGAGACAGGCCAATTTTTTAGGGAGAATTT Z1658 AAGGACACCAAATGAAAGACTGTAAT---GAGAGGCAGGCCAATTTTTTAGGGAGAATTT ************************** ***** ************************* Z1658_donor GGCCTTCCCACAAGGGGAGGCCAGGAAATTTCCTTCAGAGCAGGCCAGAGCCGACAGCTC degcon010-degen-30 GGCCTTCCCACAAGGGGAGGCCAGGAAATTTCCTTCAGAGCAGGCCAGAGCCGACAGCTC HIVGAG1|quiver GGCCTTCCCACAAGGGGAGGCCAGGAAATTTCCTTCAGAGCAGGCCAGAGCCGACAGCTC degcon038 GGCCTTCCCACAAGGGGAGGCCAGGAAATTTCCTTCAGAGCAGGCCAGAGCCGACAGCTC degcon035 GGCCTTCCCACAAGGGGAGGCCAGGAAATTTCCTTCAGAGCAGGCCAGAGCCGACAGCTC Z1658 GGCCTTCCCACAAGGGGAGGCCAGGAAATTTCCTTCAGAGCAGGCCAGAGCCGACAGCTC ************************************************************ Z1658_donor CACCAGCAGAGAGCTTCAGGTTCGAGGAAACAACCCCTGCTCCGAAGCAGGAGATGAAGG degcon010-degen-30 CACCAGCAGAGAGCTTCAGGTTCGAGGAAACAACCCCTGCTCCGAAGCAGGAGATGAAGG HIVGAG1|quiver CACCAGCAGAGAGCTTCAGGTTCGAGGAAACAACCCCTGCTCCGAAGCAGGAGATGAAGG degcon038 CACCAGCAGAGAGCTTCAGGTTCGAGGAAACAACCCCTGCTCCGAAGCAGGAGATGAAGG degcon035 CACCAGCAGAGAGCTTCAGGTTCGAGGAAACAACCCCTGCTCCGAAGCAGGAGATGAAGG Z1658 CACCAGCAGAGAGCTTCAGGTTCGAGGAAACAACCCCTGCTCCGAAGCAGGAGATGAAGG ************************************************************ Z1658_donor ACAGGGAACCCTTAACTTCCCTCAAATCACTCTTTGGCAGCGACCCCTTGTCTCAATAA- degcon010-degen-30 ACAGGGAACCCTTAACTTCCCTCAAATCACTCTTTGGCAGCGACCCCTTGTCTCAATAAA HIVGAG1|quiver ACAGGGAACCCTTAACTTCCCTCAAATCACTCTTTGGCAGCGACCCCTTGTCTCAATAAA degcon038 ACAGGGAACCCTTAACTTCCCTCAAATCACTCTTTGGCAGCGACCCCTTGTCTCAATAAA degcon035 ACAGGGAACCCTTAACTTCCCTCAAATCACTCTTTGGCAGCGACCCCTTGTCTCAATAAA Z1658 ACAGGGAACCCTTAACTTCCCTCAAATCACTCTTTGGCAGCGACCCCTTGTCTCAATAA- *********************************************************** Z1658_donor ------------------------------------------------------------ degcon010-degen-30 AGTAGGGGGCCAGATAAAGGAAGCTCTCTTAGATACAGGAGCAGATGATACAGTATTAGA HIVGAG1|quiver AGTAGGGGGCCAGATAAAGGAAGCTCTCTTAGATACAGGAGCAGATGATACAGTATTAGA degcon038 AGTAGGGGGCCAGATAAAGGAAGCTCTCTTAGATACAGGAGCAGATGATACAGTATTAGA degcon035 AGTAGGGGGCCAGATAAAGGAAGCTCTCTTAGATACAGGAGCAGATGATACAGTATTAGA Z1658 ------------------------------------------------------------ Z1658_donor ------------------------------------------------------------ degcon010-degen-30 AGACATAGARTTGCCAGGAAGATGGAAACCAAAAATGATAGGAGGAATTGGAGGTTTTAT HIVGAG1|quiver AGACATAGAGTTGCCAGGAAGATGGAAACCAAAAATGATAGGAGGAATTGGAGGTTTTAT degcon038 AGACATAGAGTTGCCAGGAAGATGGAAACCAAAAATGATAGGAGGAATTGGAGGTTTTAT degcon035 AGACATAGAGTTGCCAGGAAGATGGAAACCAAAAATGATAGGAGGAATTGGAGGTTTTAT Z1658 ------------------------------------------------------------ Z1658_donor --------------------------- degcon010-degen-30 CAAAGTRARRCARTATGATCAAATACT HIVGAG1|quiver CAAAGTAAGACAGTATGATCAAATACT degcon038 CAAAGTAAGACAGTATGATCAAATACT degcon035 CAAAGTAAGACAGTATGATCAAATACT Z1658 ---------------------------